Cortical and white matter substrates supporting visuospatial working memory.

ABSTRACT:

Objective

In tasks involving new visuospatial information, we rely on working memory, supported by a distributed brain network. We investigated the dynamic interplay between brain regions, including cortical and white matter structures, to understand how neural interactions change with different memory loads and trials, and their subsequent impact on working memory performance.

Methods

Patients undertook a task of immediate spatial recall during intracranial EEG monitoring. We charted the dynamics of cortical high-gamma activity and associated functional connectivity modulations in white matter tracts.

Results

Elevated memory loads were linked to enhanced functional connectivity via occipital longitudinal tracts, yet decreased through arcuate, uncinate, and superior-l

SUBMITTER: Ueda R 

PROVIDER: S-EPMC11102300 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature