Diet, Pace of Biological Aging, and Risk of Dementia in the Framingham Heart Study.

ABSTRACT:

Objective

People who eat healthier diets are less likely to develop dementia, but the biological mechanism of this protection is not well understood. We tested the hypothesis that healthy diet protects against dementia because it slows the pace of biological aging.

Methods

We analyzed Framingham Offspring Cohort data. We included participants ≥60 years-old, free of dementia and having dietary, epigenetic, and follow-up data. We assessed healthy diet as long-term adherence to the Mediterranean-Dash Intervention for Neurodegenerative Delay diet (MIND, over 4 visits spanning 1991-2008). We measured the pace of aging from blood DNA methylation data collected in 2005-2008 using the DunedinPACE epigenetic clock. Incident dementia and mortality were defined using study records comp

SUBMITTER: Thomas A 

PROVIDER: S-EPMC11102315 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature