Longitudinal Free-Water Changes in Dementia with Lewy Bodies.

ABSTRACT:

Background

Diffusion-weighted magnetic resonance imaging (dMRI) examines tissue microstructure integrity in vivo. Prior dementia with Lewy bodies (DLB) diffusion tensor imaging studies yielded mixed results.

Objective

We employed free-water (FW) imaging to assess DLB progression and correlate with clinical decline in DLB.

Methods

Baseline and follow-up MRIs were obtained at 12 and/or 24 months for 27 individuals with DLB or mild cognitive impairment with Lewy bodies (MCI-LB). FW was analyzed using the Mayo Clinic Adult Lifespan Template. Primary outcomes were FW differences between baseline and 12 or 24 months. To compare FW change longitudinally, we included 20 cognitively unimpaired individuals from the Alzheimer's Disease Neuroimaging Initiative.

Results

We

SUBMITTER: Chiu SY 

PROVIDER: S-EPMC11102324 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature