Transcriptomic profiling and regulatory pathways of cardiac resident macrophages in aging.

ABSTRACT: Cardiovascular diseases are an array of age-related disorders, and accumulating evidence suggests a link between cardiac resident macrophages (CRMs) and the age-related disorders. However, how does CRMs alter with aging remains elusive. In the present study, aged mice (20 months old) have been employed to check for their cardiac structural and functional alterations, and the changes in the proportion of CRM subsets as well, followed by sorting of CRMs, including C-C Motif Chemokine Receptor 2 (CCR2)⁺ and CCR2^- CRMs, which were subjected to Smart-Seq. Integrated analysis of the Smart-Seq data with three publicly available single-cell RNA-seq datasets revealed that inflammatory genes were drastic upregulated for both CCR2⁺ and CCR2^- CRMs with aging

SUBMITTER: Xia G 

PROVIDER: S-EPMC11102896 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature