A Biomarker-Based Diagnostic Model for Cardiac Dysfunction in Childhood Cancer Survivors.

ABSTRACT:

Background

Childhood cancer survivors at risk for heart failure undergo lifelong echocardiographic surveillance. Previous studies reported the limited diagnostic accuracy of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity cardiac troponin T (hs-cTnT) in detecting left ventricular (LV) dysfunction. However, potential enhanced diagnostic accuracy through the combination of biomarkers and clinical characteristics has been suggested.

Objectives

The aim of this study was to develop and internally validate a diagnostic model that combines cardiac biomarkers with clinical characteristics for effectively ruling in or ruling out LV dysfunction in childhood cancer survivors.

Methods

A multicenter cross-sectional study included 1,334 survivors (median

SUBMITTER: Leerink JM 

PROVIDER: S-EPMC11103045 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature