Hypertensive disorders of pregnancy and cardiovascular disease risk: a Mendelian randomisation study.

ABSTRACT:

Objective

Observational studies show that hypertensive disorders of pregnancy (HDPs) are related to unfavourable maternal cardiovascular disease (CVD) risk profiles later in life. We investigated whether genetic liability to pre-eclampsia/eclampsia and gestational hypertension is associated with CVD risk factors and occurrence of CVD events.

Methods

We obtained genetic associations with HDPs from a genome-wide association study and used individual participant data from the UK Biobank to obtain genetic associations with CVD risk factors and CVD events (defined as myocardial infarction or stroke). In our primary analysis, we applied Mendelian randomisation using inverse-variance weighted regression analysis in ever pregnant women. In sensitivity analyses, we studied men and nu

SUBMITTER: Tschiderer L 

PROVIDER: S-EPMC11103302 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature