Major adverse events in youth-onset type 1 and type 2 diabetes: The SEARCH and TODAY studies.

ABSTRACT:

Aims

To determine contemporary incidence rates and risk factors for major adverse events in youth-onset T1D and T2D.

Methods

Participant interviews were conducted once during in-person visits from 2018 to 2019 in SEARCH (T1D: N = 564; T2D: N = 149) and semi-annually from 2014 to 2020 in TODAY (T2D: N = 495). Outcomes were adjudicated using harmonized, predetermined, standardized criteria.

Results

Incidence rates (events per 10,000 person-years) among T1D participants were: 10.9 ophthalmologic; 0 kidney; 11.1 nerve, 3.1 cardiac; 3.1 peripheral vascular; 1.6 cerebrovascular; and 15.6 gastrointestinal events. Among T2D participants, rates were: 40.0 ophthalmologic; 6.2 kidney; 21.2 nerve; 21.2 cardiac; 10.0 peripheral vascular; 5.0 cerebrovascular and 42.8 gastrointestin

SUBMITTER: Mottl AK 

PROVIDER: S-EPMC11103672 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature