Bio-nanoparticles loaded with synovial-derived exosomes ameliorate osteoarthritis progression by modifying the oxidative microenvironment.

ABSTRACT:

Background and aims

Osteoarthritis (OA) is a prevalent degenerative joint disorder, marked by the progressive degeneration of joint cartilage, synovial inflammation, and subchondral bone hyperplasia. The synovial tissue plays a pivotal role in cartilage regulation. Exosomes (EXOs), small membrane-bound vesicles released by cells into the extracellular space, are crucial in mediating intercellular communication and facilitating the exchange of information between tissues. Our study aimed to devise a hydrogel microsphere infused with SOD3-enriched exosomes (S-EXOs) to protect cartilage and introduce a novel, effective approach for OA treatment.

Materials and methods

We analyzed single-cell sequencing data from 4247 cells obtained from the GEO database. Techniques such as PCR,

SUBMITTER: Cao H 

PROVIDER: S-EPMC11103857 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature