Characterization of the genetic variation and evolutionary divergence of the CLEC18 family.

ABSTRACT:

Background

The C-type lectin family 18 (CLEC18) with lipid and glycan binding capabilities is important to metabolic regulation and innate immune responses against viral infection. However, human CLEC18 comprises three paralogous genes with highly similar sequences, making it challenging to distinguish genetic variations, expression patterns, and biological functions of individual CLEC18 paralogs. Additionally, the evolutionary relationship between human CLEC18 and its counterparts in other species remains unclear.

Methods

To identify the sequence variation and evolutionary divergence of human CLEC18 paralogs, we conducted a comprehensive analysis using various resources, including human and non-human primate reference genome assemblies, human pangenome assemblies, and long-

SUBMITTER: Chang CM 

PROVIDER: S-EPMC11103991 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature