Effect of chain architecture on the structure, dynamics, and rheology of thermoresponsive poloxamer hydrogels and associated blends.

ABSTRACT: Poloxamers, ABA triblock polymers composed of a poly(propylene oxide) (PPO) midblock (B) and poly(ethylene oxide) (PEO) endblocks (A), are widely studied for biomedical applications. Aqueous poloxamer 407 (P407; also referred to as F127) undergoes a solution-to-gel transition with increasing temperature, driven by the formation and ordering of micelles onto periodic lattices; however, the gel temperature and resulting modulus has limited tunability. Here, reverse P407 (RP407), a BAB polymer of the same composition and molar mass but the inverted architecture, is synthesized via anionic polymerization. The micellization and gelation temperatures of RP407 are higher than that of P407 and the PPO endblocks allow for intermicelle bridging; however, both single-component solutions favor body-ce

SUBMITTER: White JM 

PROVIDER: S-EPMC11104561 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature