Frizzled 1 and Wnt1 as new potential therapeutic targets in the traumatically injured spinal cord.

ABSTRACT: Despite the experimental evidence pointing to a significant role of the Wnt family of proteins in physiological and pathological rodent spinal cord functioning, its potential relevance in the healthy and traumatically injured human spinal cord as well as its therapeutic potential in spinal cord injury (SCI) are still poorly understood. To get further insight into these interesting issues, we first demonstrated by quantitative Real-Time PCR and simple immunohistochemistry that detectable mRNA expression of most Wnt components, as well as protein expression of all known Wnt receptors, can be found in the healthy human spinal cord, supporting its potential involvement in human spinal cord physiology. Moreover, evaluation of Frizzled (Fz) 1 expression by double immunohistochemistry showed that

SUBMITTER: Gonzalez P 

PROVIDER: S-EPMC11104978 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature