The dark side of Alzheimer's disease: unstructured biology of proteins from the amyloid cascade signaling pathway.

ABSTRACT: Alzheimer's disease (AD) is a leading cause of age-related dementia worldwide. Despite more than a century of intensive research, we are not anywhere near the discovery of a cure for this disease or a way to prevent its progression. Among the various molecular mechanisms proposed for the description of the pathogenesis and progression of AD, the amyloid cascade hypothesis, according to which accumulation of a product of amyloid precursor protein (APP) cleavage, amyloid β (Aβ) peptide, induces pathological changes in the brain observed in AD, occupies a unique niche. Although multiple proteins have been implicated in this amyloid cascade signaling pathway, their structure-function relationships are mostly unexplored. However, it is known that two major proteins related to AD pathology, Aβ p

SUBMITTER: Gadhave K 

PROVIDER: S-EPMC11104979 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature