Epistasis facilitates functional evolution in an ancient transcription factor.

ABSTRACT: A protein's genetic architecture - the set of causal rules by which its sequence produces its functions - also determines its possible evolutionary trajectories. Prior research has proposed that the genetic architecture of proteins is very complex, with pervasive epistatic interactions that constrain evolution and make function difficult to predict from sequence. Most of this work has analyzed only the direct paths between two proteins of interest - excluding the vast majority of possible genotypes and evolutionary trajectories - and has considered only a single protein function, leaving unaddressed the genetic architecture of functional specificity and its impact on the evolution of new functions. Here, we develop a new method based on ordinal logistic regression to directly characterize

SUBMITTER: Metzger BPH 

PROVIDER: S-EPMC11105156 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature