Proliferation of hippocampal progenitors relies on p27-dependent regulation of Cdk6 kinase activity.

ABSTRACT: Neural stem cells give rise to granule dentate neurons throughout life in the hippocampus. Upon activation, these stem cells generate fast proliferating progenitors that complete several rounds of divisions before differentiating into neurons. Although the mechanisms regulating the activation of stem cells have been intensively studied, little attention has been given so far to the intrinsic machinery allowing the expansion of the progenitor pool. The cell cycle protein Cdk6 positively regulates the proliferation of hippocampal progenitors, but the mechanism involved remains elusive. Whereas Cdk6 functions primarily as a cell cycle kinase, it can also act as transcriptional regulator in cancer cells and hematopoietic stem cells. Using mouse genetics, we show here that the function of Cdk6

SUBMITTER: Caron N 

PROVIDER: S-EPMC11105564 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature