Dataset Information

Sex and Age Characteristics in Acute or Chronic Myocarditis A Descriptive, Multicenter Cohort Study.

ABSTRACT:

Background

Understanding the clinical features of myocarditis in various age groups is required to identify age-specific disease patterns.

Objectives

The objective of this study was to examine differences in sex distribution and clinical outcomes in patients with myocarditis of various ages.

Methods

Patients with acute or chronic myocarditis in 3 centers in Berlin, Germany from 2005 to 2021 and in the United States (National Inpatient Sample) from 2010 to 2019 were included. Age groups examined included "prepubescent" (below 11 years for females and below 13 years for males), adolescents (11 [female] or 13 [male] to 18 years), young adults (18-35 years), "middle-aged adults" (35-54 years), and older adults (age >54 years). In patients admitted to the hospital, hospital mortality, length of stay, and medical complication rates were examined.

Results

Overall, 6,023 cases in Berlin and 9,079 cases in the U.S. cohort were included. In both cohorts, there were differences in sex distribution among the 5 age categories, and differences in the distribution were most notable in adolescents (69.3% males vs 30.7% females) and in young adults (73.8% males vs 26.3% females). Prepubescent and older adults had the highest rates of in-hospital mortality, hospital length of stay, and medical complications. In the Berlin cohort, prepubescent patients had higher levels of leukocytes (P < 0.001), antistreptolysin antibody (P < 0.001), and NT-proBNP (P < 0.001) when compared to young adults.

Conclusions

In this study, we found that sex differences in myocarditis and clinical features of myocarditis were age-dependent.

SUBMITTER: Thevathasan T

PROVIDER: S-EPMC11105794 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature

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Publications

Sex and Age Characteristics in Acute or Chronic Myocarditis A Descriptive, Multicenter Cohort Study.

Thevathasan Tharusan T Kenny Megan A MA Gaul Anna L AL Paul Julia J Krause Finn J FJ Lech Sonia S Stadler Gertraud G Meyer Alexander A Schreiber Fabian F Fairweather DeLisa D Cooper Leslie T LT Tschöpe Carsten C Landmesser Ulf U Skurk Carsten C Balzer Felix F Heidecker Bettina B

JACC. Advances 20240220 4

<h4>Background</h4>Understanding the clinical features of myocarditis in various age groups is required to identify age-specific disease patterns.<h4>Objectives</h4>The objective of this study was to examine differences in sex distribution and clinical outcomes in patients with myocarditis of various ages.<h4>Methods</h4>Patients with acute or chronic myocarditis in 3 centers in Berlin, Germany from 2005 to 2021 and in the United States (National Inpatient Sample) from 2010 to 2019 were included ...[more]

PMID: 38770230

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Dataset Information

Sex and Age Characteristics in Acute or Chronic Myocarditis A Descriptive, Multicenter Cohort Study.

Background

Objectives

Methods

Results

Conclusions

Publications

Sex and Age Characteristics in Acute or Chronic Myocarditis A Descriptive, Multicenter Cohort Study.

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