First-in-human controlled inhalation of thin graphene oxide nanosheets to study acute cardiorespiratory responses.

ABSTRACT: Graphene oxide nanomaterials are being developed for wide-ranging applications but are associated with potential safety concerns for human health. We conducted a double-blind randomized controlled study to determine how the inhalation of graphene oxide nanosheets affects acute pulmonary and cardiovascular function. Small and ultrasmall graphene oxide nanosheets at a concentration of 200 μg m^-3 or filtered air were inhaled for 2 h by 14 young healthy volunteers in repeated visits. Overall, graphene oxide nanosheet exposure was well tolerated with no adverse effects. Heart rate, blood pressure, lung function and inflammatory markers were unaffected irrespective of graphene oxide particle size. Highly enriched blood proteomics analysis revealed very few differential plas

SUBMITTER: Andrews JPM 

PROVIDER: S-EPMC11106005 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature