Full-length MSP1 is a major target of protective immunity after controlled human malaria infection.

ABSTRACT: The merozoite surface protein 1 (MSP1) is the most abundant protein on the surface of the invasive merozoite stages of Plasmodium falciparum and has long been considered a key target of protective immunity. We used samples from a single controlled human malaria challenge study to test whether the full-length version of MSP1 (MSP1_FL) induced antibodies that mediated Fc-IgG functional activity in five independent assays. We found that anti-MSP1_FL antibodies induced complement fixation via C1q, monocyte-mediated phagocytosis, neutrophil respiratory burst, and natural killer cell degranulation as well as IFNγ production. Activity in each of these assays was strongly associated with protection. The breadth of MSP1-specific Fc-mediated effector functions was more str

SUBMITTER: Rosenkranz M 

PROVIDER: S-EPMC11106525 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature