Inability to rescue stalled ribosomes results in overactivation of the integrated stress response.

ABSTRACT: Endogenous and exogenous chemical agents are known to compromise the integrity of RNA and cause ribosome stalling and collisions. Recent studies have shown that collided ribosomes serve as sensors for multiple processes, including ribosome quality control (RQC) and the integrated stress response (ISR). Since RQC and the ISR have distinct downstream consequences, it is of great importance that organisms activate the appropriate process. We previously showed that RQC is robustly activated in response to collisions and suppresses the ISR activation. However, the molecular mechanics behind this apparent competition were not immediately clear. Here we show that Hel2 does not physically compete with factors of the ISR, but instead its ribosomal-protein ubiquitination activity, and downstream res

SUBMITTER: Nanjaraj Urs AN 

PROVIDER: S-EPMC11106528 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature