Clinical relevance of somatic mutations in Chinese lung adenocarcinoma and their prognostic implications for survival.

ABSTRACT:

Background

To comprehensively elucidate the genomic and mutational features of lung cancer cases, and lung adenocarcinoma (LUAD), it is imperative to conduct ongoing investigations into the genomic landscape. In this study, we aim to analyze the somatic mutation profile and assessed the significance of these informative genes utilizing a retrospective LUAD cohort.

Methods

A total of 247 Chinese samples were analyzed to exhibit the tumor somatic genomic alterations in patients with LUAD. The Cox regression analysis was employed to identify prognosis-related genes and establish a predictive model for stratifying patients with LUAD.

Results

In the Dianjiang People's Hospital (DPH) cohort, the top five frequent mutated genes were (Epidermal growth factor receptor) EGFR (6

SUBMITTER: Li T 

PROVIDER: S-EPMC11106684 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature