Survival Benefit Associated With Participation in Clinical Trials of Anticancer Drugs: A Systematic Review and Meta-Analysis.

ABSTRACT:

Importance

Many cancer clinical investigators view clinical trials as offering better care for patients than routine clinical care. However, definitive evidence of clinical benefit from trial participation (hereafter referred to as the participation effect) has yet to emerge.

Objective

To conduct a systematic review and meta-analysis of the evidence examining whether patient participation in cancer trials was associated with greater survival benefit compared with routine care.

Data sources

Studies were found through PubMed and Embase (January 1, 2000, until August 31, 2022), as well as backward and forward citation searching.

Study selection

Studies were included that compared overall survival of trial participants and routine care patients.

Data extraction

SUBMITTER: Iskander R 

PROVIDER: S-EPMC11106715 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature