Azole resistance mechanisms and population structure of the human pathogen Aspergillus fumigatus on retail plant products.

ABSTRACT: Aspergillus fumigatus is a ubiquitous saprotroph and human-pathogenic fungus that is life-threatening to the immunocompromised. Triazole-resistant A. fumigatus was found in patients without prior treatment with azoles, leading researchers to conclude that resistance had developed in agricultural environments where azoles are used against plant pathogens. Previous studies have documented azole-resistant A. fumigatus across agricultural environments, but few have looked at retail plant products. Our objectives were to determine if azole-resistant A. fumigatus is prevalent in retail plant products produced in the United States (U.S.), as well as to identify the resistance mechanism(s) and population genetic structure of these isolates. Five hundred twenty-five isol

SUBMITTER: Wang C 

PROVIDER: S-EPMC11107156 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature