Alterations in CD4⁺ T-cell Subsets in Living Donor Liver Transplantation Associated With Graft Rejection.

ABSTRACT:

Background and objectives

Regulatory T-cells (Tregs) play a key role in immune homeostasis after organ transplantation. However, the role of CD4⁺ T cell subsets in early acute rejection is still not well understood. Therefore, our aim was to determine changes in CD4⁺ T-cell subsets in living donor liver transplantation (LDLT).

Methods

LDLT patients were assessed for T-cell subsets, Tregs frequencies and their functionality by flow-cytometry at peri- and post-transplant in the span of 1 year.

Results

33 patients were followed up and 11 (33%) patients have developed early acute cellular rejection (ACR). At peri-transplant time point, MFI of Foxp3⁺ Tregs was significantly increased compared to HC (P = 0.04). However, CD4⁺

SUBMITTER: Vagadiya A 

PROVIDER: S-EPMC11107238 | biostudies-literature | 2024 Sep-Oct

REPOSITORIES: biostudies-literature