Assessment of causal associations between obesity and peripheral artery disease: a bidirectional Mendelian randomization study.

ABSTRACT:

Background

Several observational studies have documented a potential link between obesity and peripheral artery disease (PAD), although conflicting findings exist. The causal relationship between obesity and PAD continues to be a subject of ongoing debate in the medical community.

Objectives

In this study, we employed a bidirectional Mendelian randomization (MR) analysis to explore the potential causal relationship between obesity and the risk of PAD.

Methods

To investigate these causal relationships, we conducted bidirectional MR analysis using publicly available genome-wide association study (GWAS) data. Effect estimates were calculated using the random-effects inverse variance-weighted (IVW) method.

Results

We identified eight independent single nucleotide p

SUBMITTER: Huang XW 

PROVIDER: S-EPMC11107290 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature