Genome-wide DNA methylation analysis in female veterans with military sexual trauma and comorbid PTSD/MDD.

ABSTRACT:

Background

Military sexual trauma (MST) is a prevalent issue within the U.S. military. Victims are more likely to develop comorbid diseases such as posttraumatic stress disorder (PTSD) and major depressive disorder (MDD). Nonetheless, not everyone who suffers from MST develops PTSD and/or MDD. DNA methylation, which can regulate gene expression, might give us insight into the molecular mechanisms behind this discrepancy. Therefore, we sought to identify genomic loci and enriched biological pathways that differ between patients with and without MST, PTSD, and MDD.

Methods

Saliva samples were collected from 113 female veterans. Following DNA extraction and processing, DNA methylation levels were measured through the Infinium HumanMethylationEPIC BeadChip array. We used limma a

SUBMITTER: Marra PS 

PROVIDER: S-EPMC11107447 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature