Genetic associations between Rapid Eye Movement (REM) sleep behavior disorder and cardiovascular diseases.

ABSTRACT:

Background

Previous studies revealed that sleep disorders are potential risk factors for cardiovascular diseases, such as obstructive sleep apnea and rapid eye movement (REM) sleep behavior disorder (RBD). However, the causal associations between RBD and cardiovascular diseases remained unknown.

Materials and methods

We used the latest and largest summary-level genome-wide association studies of RBD, stroke and its subtypes, coronary artery disease (CAD), myocardial infarction (MI), and heart failure (HF) to select genetic variants as the instrumental variables. Mendelian randomization (MR) analysis was performed to test the causal associations between RBD and the cardiovascular diseases above. Inverse variance weighted method was used as the main analysis.

Results

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SUBMITTER: Xu P 

PROVIDER: S-EPMC11108173 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature