Two polygenic mouse models of major depressive disorders identify TMEM161B as a potential biomarker of disease in humans.

ABSTRACT: Treatments are only partially effective in major depressive disorders (MDD) but no biomarker exists to predict symptom improvement in patients. Animal models are essential tools in the development of antidepressant medications, but while recent genetic studies have demonstrated the polygenic contribution to MDD, current models are limited to either mimic the effect of a single gene or environmental factor. We developed in the past a model of depressive-like behaviors in mice (H/Rouen), using selective breeding based on behavioral reaction after an acute mild stress in the tail suspension test. Here, we propose a new mouse model of depression (H-TST) generated from a more complex genetic background and based on the same selection process. We first demonstrated that H/Rouen and H-TST mice ha

SUBMITTER: El Yacoubi M 

PROVIDER: S-EPMC11109134 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature