HIV immunological non-responders are characterized by extensive immunosenescence and impaired lymphocyte cytokine production capacity.

ABSTRACT:

Introduction

Immunological non-responders (INR) are people living with HIV (PLHIV) who fail to fully restore CD4+ T-cell counts despite complete viral suppression with antiretroviral therapy (ART). INR are at higher risk for non-HIV related morbidity and mortality. Previous research suggest persistent qualitative defects.

Methods

The 2000HIV study (clinical trials NTC03994835) enrolled 1895 PLHIV, divided in a discovery and validation cohort. PLHIV with CD4 T-cell count <350 cells/mm³ after ≥2 years of suppressive ART were defined as INR and were compared to immunological responders (IR) with CD4 T-cell count >500 cells/mm³. Logistic and rank based regression were used to analyze clinical data, extensive innate and adaptive immunophenotyping, and ex

SUBMITTER: Vos WAJW 

PROVIDER: S-EPMC11109418 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature