Crosstalk between human immunodeficiency virus infection and salivary bacterial function in men who have sex with men.

ABSTRACT:

Background

Engaging in anal sexual intercourse markedly increases the risk of developing HIV among men who have sex with men (MSM); oral sexual activities tend to uniquely introduce gut-derived microbes to salivary microbiota, which, combined with an individual's positive HIV status, may greatly perturb oral microecology. However, till date, only a few published studies have addressed this aspect.

Methods

Based on 16S rRNA sequencing data of bacterial taxa, MicroPITA picks representative samples for metagenomic analysis, effectively revealing how the development and progression of the HIV disease influences oral microbiota in MSM. Therefore, we collected samples from 11 HIV-negative and 44 HIV-positive MSM subjects (stage 0 was defined by HIV RNA positivity, but negative or

SUBMITTER: Guo Y 

PROVIDER: S-EPMC11109444 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature