NFAT activation by FKBP52 promotes cancer cell proliferation by suppressing p53.

ABSTRACT: FK506-binding protein 52 (FKBP52) is a member of the FKBP family of proline isomerases. FKBP52 is up-regulated in various cancers and functions as a positive regulator of steroid hormone receptors. Depletion of FKBP52 is known to inhibit cell proliferation; however, the detailed mechanism remains poorly understood. In this study, we found that FKBP52 depletion decreased MDM2 transcription, leading to stabilization of p53, and suppressed cell proliferation. We identified NFATc1 and NFATc3 as transcription factors that regulate MDM2 We also found that FKBP52 associated with NFATc3 and facilitated its nuclear translocation. In addition, calcineurin, a well-known Ca²⁺ phosphatase essential for activation of NFAT, plays a role in MDM2 transcription. Supporting th

SUBMITTER: Hanaki S 

PROVIDER: S-EPMC11109481 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature