Experimental colitis in young Tg2576 mice accelerates the onset of an Alzheimer's-like clinical phenotype.

ABSTRACT: Systemic inflammation and neuroinflammation affect the natural course of the sporadic form of Alzheimer's disease (AD), as supported by epidemiological and preclinical data, and several epidemiological studies indicate a higher prevalence of AD in patients with inflammatory bowel disease. In this study, we explored whether colitis induced by dextran sulfate sodium (DSS) in young, presymptomatic/preplaque mice worsens and/or anticipates age-dependent cognitive impairment in Tg2576, a widely used mouse model of AD. We demonstrated that DSS colitis induced in young Tg2576 mice anticipates the onset age of learning and memory deficit in the Morris water maze test. To explore potential mechanisms behind the acceleration of cognitive decline in Tg2576 mice by DSS colitis, we focused on gut micro

SUBMITTER: Lorenzini L 

PROVIDER: S-EPMC11110243 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature