Pathogenicity and escape to pre-existing immunity of a new genotype of swine influenza H1N2 virus that emerged in France in 2020.

ABSTRACT: In 2020, a new genotype of swine H1N2 influenza virus (H1_avN2-HA 1C.2.4) was identified in France. It rapidly spread within the pig population and supplanted the previously predominant H1_avN1-HA 1C.2.1 virus. To characterize this new genotype which is genetically and antigenically distant from the other H1_avNx viruses detected in France, an experimental study was conducted to compare the outcomes of H1_avN2 and H1_avN1 infections in pigs and evaluate the protection conferred by the only inactivated vaccine currently licensed in Europe containing an HA 1C (clade 1C.2.2) antigen. Infection with H1_avN2 induced stronger clinical signs and earlier shedding than H1_avN1. The neutralizing antibodies produced following H1

SUBMITTER: Deblanc C 

PROVIDER: S-EPMC11110284 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature