Genetic prediction of the relationship between metabolic syndrome and colorectal cancer risk: a Mendelian randomization study.

ABSTRACT:

Background

Despite a growing body of observational studies indicating a potential link between metabolic syndrome and colorectal cancer, a definitive causal relationship has yet to be established. This study aimed to elucidate the causal relationship between metabolic syndrome and colorectal cancer through Mendelian randomization.

Methods

We screened for instrumental variables associated with metabolic syndrome and its diagnostic components and with colorectal cancer through the use of a genome-wide association study database, and conducted a preliminary Mendelian randomization analysis. To corroborate the dependability of our conclusions, an additional dataset was used for replication analysis in a Mendelian randomization method, which was further integrated with a meta-ana

SUBMITTER: Yuan C 

PROVIDER: S-EPMC11110320 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature