Identification of plasma protein markers of allergic disease risk: a mendelian randomization approach to proteomic analysis.

ABSTRACT:

Background

While numerous allergy-related biomarkers and targeted treatment strategies have been developed and employed, there are still signifcant limitations and challenges in the early diagnosis and targeted treatment for allegic diseases. Our study aims to identify circulating proteins causally associated with allergic disease-related traits through Mendelian randomization (MR)-based analytical framework.

Methods

Large-scale cis-MR was employed to estimate the effects of thousands of plasma proteins on five main allergic diseases. Additional analyses including MR Steiger analyzing and Bayesian colocalisation, were performed to test the robustness of the associations; These findings were further validated utilizing meta-analytical methods in the replication analysis. Both

SUBMITTER: Cao Z 

PROVIDER: S-EPMC11110418 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature