Antitubercular activity of 2-mercaptobenzothiazole derivatives targeting <i>Mycobacterium tuberculosis</i> type II NADH dehydrogenase.

ABSTRACT: Mycobacterium tuberculosis (Mtb) type II NADH dehydrogenase (NDH-2) transports electrons into the mycobacterial respiratory pathway at the cost of reduction of NADH to NAD⁺ and is an attractive drug target. Herein, we have synthesised a series of 2-mercaptobenzothiazoles (C1-C14) and evaluated their anti-tubercular potential as Mtb NDH-2 inhibitors. The synthesised compounds C1-C14 were evaluated for MIC₉₀ and ATP depletion against Mtb H37Ra, M. bovis, and Mtb H37Rv mc² 6230. Compounds C3, C4, and C11 were found to be the active molecules in the series and were further evaluated for their MIC₉₀ against Mtb-resistant strains and for their bactericidal potential against Mtb H37Rv mc²

SUBMITTER: Saha P 

PROVIDER: S-EPMC11110738 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature