Conserved immuno-collagenic subtypes predict response to immune checkpoint blockade.

ABSTRACT:

Background

Immune checkpoint blockade (ICB) has revolutionized the treatment of various cancer types. Despite significant preclinical advancements in understanding mechanisms, identifying the molecular basis and predictive biomarkers for clinical ICB responses remains challenging. Recent evidence, both preclinical and clinical, underscores the pivotal role of the extracellular matrix (ECM) in modulating immune cell infiltration and behaviors. This study aimed to create an innovative classifier that leverages ECM characteristics to enhance the effectiveness of ICB therapy.

Methods

We analyzed transcriptomic collagen activity and immune signatures in 649 patients with cancer undergoing ICB therapy. This analysis led to the identification of three distinct immuno-collagenic sub

SUBMITTER: Mei J 

PROVIDER: S-EPMC11110954 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature