IL-1β Inhibition Partially Negates the Beneficial Effects of Diet-Induced Atherosclerosis Regression in Mice.

ABSTRACT:

Background

Thromboembolic events secondary to rupture or erosion of advanced atherosclerotic lesions is the global leading cause of death. The most common and effective means to reduce these major adverse cardiovascular events, including myocardial infarction and stroke, is aggressive lipid lowering via a combination of drugs and dietary modifications. However, we know little regarding the effects of reducing dietary lipids on the composition and stability of advanced atherosclerotic lesions, the mechanisms that regulate these processes, and what therapeutic approaches might augment the benefits of lipid lowering.

Methods

Smooth muscle cell lineage-tracing Apoe^-/- mice were fed a high-cholesterol Western diet for 18 weeks and then a zero-cholesterol standar

SUBMITTER: Karnewar S 

PROVIDER: S-EPMC11111338 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature