Diffusion imaging markers of accelerated aging of the lower cingulum in subjective cognitive decline.

ABSTRACT:

Introduction

Alzheimer's Disease (AD) typically starts in the medial temporal lobe, then develops into a neurodegenerative cascade which spreads to other brain regions. People with subjective cognitive decline (SCD) are more likely to develop dementia, especially in the presence of amyloid pathology. Thus, we were interested in the white matter microstructure of the medial temporal lobe in SCD, specifically the lower cingulum bundle that leads into the hippocampus. Diffusion tensor imaging (DTI) has been shown to differentiate SCD participants who will progress to mild cognitive impairment from those who will not. However, the biology underlying these DTI metrics is unclear, and results in the medial temporal lobe have been inconsistent.

Methods

To better characterize the mi

SUBMITTER: Flaherty R 

PROVIDER: S-EPMC11111894 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature