Clcn3 deficiency ameliorates high-fat diet-induced obesity and improves metabolism in mice.

ABSTRACT:

Objective

Obesity is defined as excess body fat and is a current health epidemic associated with increased risk for type 2 diabetes and cardiovascular disease. The ClC-3 chloride channel/antiporter, encoded by the Clcn3, is associated with some diseases, like carcinoma, nervous system diseases, and metabolic diseases. To verify the relationship between the Clcn3 and weight including metabolic changes, searching for a new target for metabolic therapy of obesity, we designed the experiment.

Methods

The mice were divided into 4 different groups: Clcn3^+/+ mice + high-fat diet (HFD), Clcn3^-/- mice + HFD, Clcn3^+/+ mice + normal diet (ND), Clcn3^-/- mice + ND, and fed for 16 weeks. After the glucos

SUBMITTER: Duan S 

PROVIDER: S-EPMC11111939 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature