Vitamin D level in COVID-19 patients has positive correlations with autophagy and negative correlations with disease severity.

ABSTRACT:

Background and objectives

There is still incomplete understanding of the pathogenesis of COVID-19. Calcitriol, the main form of vitamin D in serum, regulates immune responses and increases resistance to pathogens, but the mechanism by which it protects against COVID-19 is uncertain. Autophagy has antiviral effects and helps to maintain homeostasis, but its specific role in COVID-19 is also uncertain. Both vitamin D and autophagy have important functions in the lung microenvironment. This study examined the relationship of serum vitamin D and autophagy-related proteins in patients with COVID-19 and evaluated their potential use as biomarkers.

Methods

Blood samples from COVID-19 patients at the Second Hospital of Jilin University were collected. The levels of vitamin D, autoph

SUBMITTER: Dong H 

PROVIDER: S-EPMC11112027 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature