Methadone in combination with medetomidine as premedication prior to ovariohysterectomy and castration in the cat.

ABSTRACT:

Objectives

The aim of the study was to evaluate the tolerability, sedative and analgesic effects of methadone in combination with medetomidine for premedication prior to neutering in healthy cats.

Methods

This was an assessor-blinded, randomised, clinical research study. Forty-five cats were recruited and divided into three treatment groups of 15. Following premedication with medetomidine (20 µg/kg) and one of the three test drugs - methadone 0.5 mg/kg, buprenorphine 20 µg/kg or butorphanol 0.4 mg/kg intramuscularly - anaesthesia was induced with propofol and maintained with isoflurane, and neutering was carried out. Sedation and physiological parameters were assessed before premedication, after premedication before induction of anaesthesia, and at 90 mins and 2, 3, 4, 6, 7,

SUBMITTER: Slingsby LS 

PROVIDER: S-EPMC11112194 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature