Genome-wide interaction study of dietary intake of fibre, fruits, and vegetables with risk of colorectal cancer.

ABSTRACT:

Background

Consumption of fibre, fruits and vegetables have been linked with lower colorectal cancer (CRC) risk. A genome-wide gene-environment (G × E) analysis was performed to test whether genetic variants modify these associations.

Methods

A pooled sample of 45 studies including up to 69,734 participants (cases: 29,896; controls: 39,838) of European ancestry were included. To identify G × E interactions, we used the traditional 1--degree-of-freedom (DF) G × E test and to improve power a 2-step procedure and a 3DF joint test that investigates the association between a genetic variant and dietary exposure, CRC risk and G × E interaction simultaneously.

Findings

The 3-DF joint test revealed two significant loci with p-value <5 × 10^-8. Rs4730274 close to the

SUBMITTER: Papadimitriou N 

PROVIDER: S-EPMC11112268 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature