Associations between behavioral and self-reported impulsivity, brain structure, and genetic influences in middle childhood.

ABSTRACT: Impulsivity undergoes a normative developmental trajectory from childhood to adulthood and is thought to be driven by maturation of brain structure. However, few large-scale studies have assessed associations between impulsivity, brain structure, and genetic susceptibility in children. In 9112 children ages 9-10 from the ABCD study, we explored relationships among impulsivity (UPPS-P impulsive behavior scale; delay discounting), brain structure (cortical thickness (CT), cortical volume (CV), and cortical area (CA)), and polygenic scores for externalizing behavior (PGS_EXT). Both higher UPPS-P total scores and more severe delay-discounting had widespread, low-magnitude associations with smaller CA in frontal and temporal regions. No associations were seen between impulsivity and C

SUBMITTER: Gilman JM 

PROVIDER: S-EPMC11112269 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature