Exploring the impact of breast cancer on colonization resistance of mouse microbiota using network node manipulation.

ABSTRACT: Breast cancer, a global health concern affecting women, has been linked to alterations in the gut microbiota, impacting various aspects of human health. This study investigates the interplay between breast cancer and the gut microbiome, particularly focusing on colonization resistance-an essential feature of the microbiota's ability to prevent pathogenic overgrowth. Using a mouse model of breast cancer, we employ diversity analysis, co-occurrence network analysis, and robustness tests to elucidate the impact of breast cancer on microbiome dynamics. Our results reveal that breast cancer exposure affects the bacterial community's composition and structure, with temporal dynamics playing a role. Network analysis demonstrates that breast cancer disrupts microbial interactions and decreases net

SUBMITTER: Wu-Chuang A 

PROVIDER: S-EPMC11112314 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature