Gut microbiota-metabolite interactions meditate the effect of dietary patterns on precocious puberty.

ABSTRACT: Precocious puberty, a pediatric endocrine disorder classified as central precocious puberty (CPP) or peripheral precocious puberty (PPP), is influenced by diet, gut microbiota, and metabolites, but the specific mechanisms remain unclear. Our study found that increased alpha-diversity and abundance of short-chain fatty acid-producing bacteria led to elevated levels of luteinizing hormone and follicle-stimulating hormone, contributing to precocious puberty. The integration of specific microbiota and metabolites has potential diagnostic value for precocious puberty. The Prevotella genus-controlled interaction factor, influenced by complex carbohydrate consumption, mediated a reduction in estradiol levels. Interactions between obesity-related bacteria and metabolites mediated the benefi

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11112371 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature