Post-polio syndrome is not a dysimmune condition.

ABSTRACT:

Background

Poliomyelitis is a global disabling disease affecting 12-20 million of people. Post poliomyelitis syndrome (PPS) may affect up to 80% of polio survivors: increased muscle weakness, pain, fatigue, functional decline. It relies on aging of an impaired neuro-muscular system with ongoing denervation processes. A late involvement of humoral or cellular pro-inflammatory phenomena is also suspected.

Aim

To assess the dysimmune hypothesis of PPS by comparing lymphocyte subpopulations and humoral immune factors between PPS patients and controls.

Design

Cross-sectional study.

Setting

Montpellier University Hospital.

Population

Forty-seven PPS and 27 healthy controls.

Methods

PPS patients and controls were compared on their lymphocyte subpopulatio

SUBMITTER: Laffont I 

PROVIDER: S-EPMC11112507 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature