An association between elevated telomerase reverse transcriptase expression and the immune tolerance disruption of dendritic cells.

ABSTRACT:

Background

To elucidate the mechanism of dysfunction of tolerogenic dendritic cells (DCs) is of significance. Telomerase involves the regulation of the cell fate and activities. The objective of this study is to investigate the role of telomerase reverse transcriptase (TERT) in regulating the tolerogenic feature of DCs.

Methods

The telomerase was assessed in DCs, which were collected from patients with allergic rhinitis (AR), healthy control (HC) subjects, and mice. RNAs were extracted from DCs, and analyzed by RNA sequencing (RNAseq), real-time quantitative RT-PCR, and Western blotting.

Results

The results showed that expression of TERT was higher in peripheral DCs of AR patients. The expression of IL10 in DCs was negatively correlated with the levels of TERT express

SUBMITTER: Xu X 

PROVIDER: S-EPMC11112790 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature