Role of LsrR in the regulation of biofilm formation in mammary pathogenic Escherichia coli.

ABSTRACT:

Background

Mammary Pathogenic Escherichia coli (MPEC) is an important pathogen that can escape the attack of the host immune system through biofilm formation and proliferate in the mammary gland continuously, resulting in mastitis in cows and causing enormous economic losses. As an effector of AI-2 quorum sensing, LsrR extensively affects the expression levels of hundreds of genes related to multiple biological processes in model E. coli strain. However, the regulatory role of LsrR in MPEC and whether it is involved in pathogenesis has been seldom reported.

Results

In this study, the function of LsrR in strain MPEC5, obtained from a milk sample in dairy cows with mastitis, was investigated by performing high-throughput sequencing (RNA-seq) assays. The results revealed that L

SUBMITTER: Xu L 

PROVIDER: S-EPMC11112850 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature