Unveiling the genetic architecture and transmission dynamics of a novel multidrug-resistant plasmid harboring bla_NDM-5 in E. Coli ST167: implications for antibiotic resistance management.

ABSTRACT:

Background

The emergence of multidrug-resistant (MDR) Escherichia coli strains poses significant challenges in clinical settings, particularly when these strains harbor New Delhi metallo-ß-lactamase (NDM) gene, which confer resistance to carbapenems, a critical class of last-resort antibiotics. This study investigates the genetic characteristics and implications of a novel bla_NDM-5-carrying plasmid pNDM-5-0083 isolated from an E. coli strain GZ04-0083 from clinical specimen in Zhongshan, China.

Results

Phenotypic and genotypic evaluations confirmed that the E. coli ST167 strain GZ04-0083 is a multidrug-resistant organism, showing resistance to diverse classes of antibiotics including ß-lactams, carbapenems, fluoroquinolones, aminoglycosides, and sulfonamides, whil

SUBMITTER: Han D 

PROVIDER: S-EPMC11112900 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature