Clinical validation of C₁₂FDG as a marker associated with senescence and osteoarthritic phenotypes.

ABSTRACT: Chronic conditions associated with aging have proven difficult to prevent or treat. Senescence is a cell fate defined by loss of proliferative capacity and the development of a pro-inflammatory senescence-associated secretory phenotype comprised of cytokines/chemokines, proteases, and other factors that promotes age-related diseases. Specifically, an increase in senescent peripheral blood mononuclear cells (PBMCs), including T cells, is associated with conditions like frailty, rheumatoid arthritis, and bone loss. However, it is unknown if the percentage of senescent PBMCs associated with age-associated orthopedic decline could be used for potential diagnostic or prognostic use in orthopedics. Here, we report senescent cell detection using the fluorescent compound C₁₂FDG to quant

SUBMITTER: Hambright WS 

PROVIDER: S-EPMC11113632 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature