Systematic evaluation and meta-analysis of the prognosis of down-staging human papillomavirus (HPV) positive oropharyngeal squamous cell carcinoma using cetuximab combined with radiotherapy instead of cisplatin combined with radiotherapy.

ABSTRACT:

Objective

To evaluate the efficacy and safety of cetuximab instead of cisplatin in combination with downstaging radiotherapy for papillomavirus (HPV) positive oropharyngeal squamous cell carcinoma (HPV⁺ OPSCC).

Design

Meta-analysis and systematic evaluation.

Data sources

The PubMed, Embase, Web of Science, and Cochrane library databases were searched up to June 8, 2023, as well as Clinicaltrials.gov Clinical Trials Registry, China Knowledge Network, Wanfang Data Knowledge Service Platform, and Wiprojournal.com.

Eligibility criteria for selecting studies

Randomized controlled trials reporting results of standard regimens of cetuximab + radiotherapy vs cisplatin + radiotherapy in treating HPV⁺ OPSCC were included. The primary outcomes of int

SUBMITTER: Hu Q 

PROVIDER: S-EPMC11114112 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature